
Alex Mandel
I am currently in charge of chemistry in a new effort to develop targeted radiotherapeutics. Radioimmunotherapy promises to... | Vancouver, Vancouver, Canada
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Alex Mandel’s Location Vancouver, Vancouver, Canada
Alex Mandel’s Expertise I am currently in charge of chemistry in a new effort to develop targeted radiotherapeutics. Radioimmunotherapy promises to extend the cancer fighting power of radiotherapy by targeting radiation directly to the tumor site. While modern targeted radiotherapies have shown good safety profiles, these complex drug products present unique and fascinating intellectual challenges in their implementations. With so many design aspects to consider, they can be readily tuned to treat many different cancers and even some non-malignant diseases From 2002, I have developed my synthetic chemistry with proficiency in multitasking and experimental design. I am responsible for coordinating multiple high priority projects. Some of these efforts involve extensive due diligence into disease targets and pathways to decide on the optimal molecular approach. My skills developed while working in a team to build a cytotoxic antibody-drug conjugate (ADC) platform that was spun out to Zymeworks to become their Zymelink technology. Now I get to formulate and test ideas that span a spectrum from nuclear physics through chemistry and protein science to cancer biology. Besides applying traditional medicinal chemistry to pursue drug candidates, I draw upon experience in chemical biology to devise novel strategies for biologics and conjugates. In order to maximize the effects of any molecular therapeutic strategy, we must invoke chemical biology and consider the structural, mechanistic, and biological aspects of the drug delivery platform. Beyond synthetic chemistry, I am interested in intellectual property and how it affects the course of research and technological development. I also enjoy integrating new disciplines into my work through collaboration and learning from more experienced colleagues. Life-threatening infectious diseases and cancer are the two focal points of my research. The desire to ease suffering motivates me to devote my skills and practice to healthcare, as I have seen firsthand how far we are from ideal treatments.
Alex Mandel’s Current Industry Abdera Therapeutics
Alex
Mandel’s Prior Industry
University Of Washington
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University Of California At San Diego
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Espci
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National University
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Cactus Communications
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Centre For Drug Research And Development
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The Centre For Drug Research And Development
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Admare Bioinnovations
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Abdera Therapeutics
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Work Experience

Abdera Therapeutics
Director of Chemistry
Mon Jan 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Abdera Therapeutics
Senior Scientist
Tue Mar 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Aug 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Admare Bioinnovations
Senior Scientist
Mon Apr 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
The Centre For Drug Research And Development
Scientist
Sat Apr 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Apr 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Centre For Drug Research And Development
Associate Scientist
Thu Nov 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Apr 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Centre For Drug Research And Development
Postdoctoral Fellow
Sun Apr 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Oct 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time)
Cactus Communications
Editor
Thu Sep 01 2011 00:00:00 GMT+0000 (Coordinated Universal Time) — Thu Mar 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time)
National University
Research Fellow
Wed Sep 01 2010 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Aug 01 2011 00:00:00 GMT+0000 (Coordinated Universal Time)
Espci
Postdoctoral Researcher
Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun Feb 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time)
University Of California At San Diego
Graduate Research and Teaching Assistant
Sun Sep 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Dec 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time)
University Of Washington
Programming Scientist
Mon May 01 2000 00:00:00 GMT+0000 (Coordinated Universal Time) — Thu Aug 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time)