
Andrew Combs
I am a C-level executive setting research strategy and executing on the invention of novel first-in-class and best-in-class... | Wilmington, Delaware, United States
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Andrew Combs’s Emails ac****@pr****.com
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Andrew Combs’s Location Wilmington, Delaware, United States
Andrew Combs’s Expertise I am a C-level executive setting research strategy and executing on the invention of novel first-in-class and best-in-class therapeutics. Mentoring innovative chemists to design and synthesize novel drugs has been my passion for nearly 30 years of research within the pharmaceutical and biotechnology industries. I have led teams to >10 clinical candidates, which include a broad range of modalities such as, kinase inhibitors, dioxygenase inhibitors, epigenetic inhibitors, inhibitors of protein-protein interactions, and most recently targeted protein degraders. My research interests embrace the application of innovative technologies to expedite the drug discovery process, including AI and ML tools that enable structure-based drug design, targeted protein degradation, fragment based approaches, preparative LCMS purification and microwave synthesis technologies. I am a co-author on >75 research articles/book chapters, been granted >65 US patents, presented numerous invited lectures, served on editorial boards of scientific journals (currently J. Med. Chem. Letters), co-chaired >10 ACS conferences, served on a variety of NIH review panels. Currently I am a member of the SAB for Boston University CMD and the University of Delaware NIH-funded COBRE and I am an adjunct Professor at the University of Delaware. I hold BS degrees in Chemistry and Molecular Biology from the University of Wisconsin-Madison, a PhD in Organic Chemistry from University of California, Los Angeles, and completed my training as a Howard Hughes Medical Institute post-doctoral fellow at Harvard University.
Andrew Combs’s Current Industry Prelude Therapeutics
Andrew
Combs’s Prior Industry
Dupont Dupontmerck Pharmaceuticals
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Bristol Myers Squibb
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Incyte
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Combs Medicinal Chemistry Consulting
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Prelude Therapeutics
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Work Experience

Prelude Therapeutics
Chief Chemistry Officer
Fri Mar 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Combs Medicinal Chemistry Consulting
President
Fri Feb 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Mar 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Incyte
Sr. Director to Vice President
Wed Jan 01 2003 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Feb 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Bristol Myers Squibb
Director
Tue Jan 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time) — Wed Jan 01 2003 00:00:00 GMT+0000 (Coordinated Universal Time)
Dupont Dupontmerck Pharmaceuticals
Sr Research Scientist to Director
Mon Apr 01 1996 00:00:00 GMT+0000 (Coordinated Universal Time) — Thu Aug 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time)