
Goutam Chowdhury
In vitro studies towards understanding the molecular mechanism of metabolism and genotoxicity of various drugs, environmental agents and... | Noida, Uttar Pradesh, India
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Goutam Chowdhury’s Emails go****@sn****.edu
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Goutam Chowdhury’s Location Noida, Uttar Pradesh, India
Goutam Chowdhury’s Expertise In vitro studies towards understanding the molecular mechanism of metabolism and genotoxicity of various drugs, environmental agents and small molecules. The goals are to understand the mechanism of cellular metabolism/activation of these molecules by cytochrome P450s and other enzymes, detection and structure elucidation of metabolites and any reactive intermediates formed, and finally detection of DNA and protein damages caused by these agents. I have worked with various small molecules including tirapazamine (antitumor drug in phase III clinical trials), thalidomide (approved for the treatment of multiple myeloma), arylamines and nitrosomines (procarcinogens). I have worked with P450s including 3A4, 2A6, 2D6, 2E1 and liver microsomes on the biotransformation/metabolism of small molecules. I have worked towards detection and structure elucidation of small molecules (including drug metabolites, GSH conjugates and small molecule AhR agonists) and macromolecules (including oligonucleotides and peptide-DNA crosslinks) using primarily LC/MS-MS and NMR methodologies. Authored more than 30 peer reviewed publications. Specialties: Drug Metabolism/Biotransformation, Metabolite ID, Analytical chemistry (LC-tandem MS, GC-MS, UPLC), structure elucidation, Chemical Biology, Chemical Toxicology, DNA chemistry
Goutam Chowdhury’s Current Industry Shiv Nadar University
Goutam
Chowdhury’s Prior Industry
Vanderbilt University
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Vanderbilt University Medical Center
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Covance
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Shiv Nadar University
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Work Experience

Shiv Nadar University
Assistant Professor
Tue Jul 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Apr 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Covance
Scientist
Tue Jan 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun Jun 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time)
Vanderbilt University Medical Center
Research Instructor
Thu Jan 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time) — Wed May 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time)
Vanderbilt University
Postdoctoral Fellow
Sun Jan 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Dec 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time)