
Hui Yu
A well trained, creative, passionate, conscientious, data driven and accomplished synthetic medicinal chemist in small molecule drug discovery... | Cambridge, Massachusetts, United States
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Hui Yu’s Location Cambridge, Massachusetts, United States
Hui Yu’s Expertise A well trained, creative, passionate, conscientious, data driven and accomplished synthetic medicinal chemist in small molecule drug discovery research has 15 years of extensive experiences in organic synthesis and drug design. Made significant contributions for several research projects to deliver pre-clinical compounds or reach project milestones. The molecular targets worked on include integrins, kinases, enzymes, GPCRs and transporters. The corresponding disease types include autoimmune disease, IBD, diabetes and diabetic nephropathy. Key skills: • Organic synthesis. Independently design and execute multistep and parallel synthesis, organometallic, asymmetric and heterocyclic chemistry, microwave reactions and product scale-up in a timely manner. Mechanism-based trouble shooting skills aided by good understanding of NMR, LC-MS, and focus on details. Experience in organic compound recrystallization. • SAR analysis. Skillful in SAR analysis and able to generate new ideas accordingly. Skillful in balancing multiple parameters during lead optimization. Experience in lead identification and hit triage. • Drug design. Track record supported drug design skills especially structure-based drug design. Able to apply MOE to molecular modeling, drug design, known SAR interpretation and activity/property prediction. Able to apply critical thinking and knowledge of medicinal chemistry, drug-like properties and ADMET to drug design. • CRO coordination. Five years of experience in coordinating chemistry outsourcing (CRO). Other skills: • Biotage silica gel chromatography and Gilson reverse phase prep-HPLC. • Electronic laboratory notebooks. • Microsoft Word, PowerPoint, Excel, and Outlook. • Literature/patent search via SciFinder, Reaxys, etc. • MarvinSketch, ChemDraw, Symyx Draw, ISIS/Draw, and Spotfire. • Good communication and presentation skills with clear logic. • Patent analysis and (experimental) writing. • Writing of Hazardous Chemicals Best Practices.
Hui Yu’s Current Industry Wave Life Sciences
Hui
Yu’s Prior Industry
Boehringer Ingelheim
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Wave Life Sciences
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Work Experience

Wave Life Sciences
Senior Scientist I,Medicinal Chemistry
Sat Jan 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Wave Life Sciences
Scientist II, Medicinal Chemistry
Wed Jul 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Jan 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Wave Life Sciences
Staff Scientist I, Medicinal Chemistry
Sat Feb 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) — Wed Jul 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Wave Life Sciences
Scientist, Medicinal Chemistry
Sat Jul 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Feb 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Boehringer Ingelheim
Research Scientist III
Sun Jan 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) — Wed Feb 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Boehringer Ingelheim
Research Scientist II
Mon Jan 01 2001 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun Jan 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time)