
Joshua Gross
I am an academic neuropharmacologist with expertise in G protein-coupled receptor (GPCR) signaling, nutritional neuroscience, neuroendocrine physiology, and... | Durham, Durham, United States
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Joshua Gross’s Emails jo****@du****.edu
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Joshua Gross’s Location Durham, Durham, United States
Joshua Gross’s Expertise I am an academic neuropharmacologist with expertise in G protein-coupled receptor (GPCR) signaling, nutritional neuroscience, neuroendocrine physiology, and preclinical drug discovery. I obtained my PhD from West Virginia University (WVU) in Cellular & Integrative Physiology under the mentorship of Drs. David Siderovski and Vincent Setola, where I studied the intracellular regulation of opioid receptor signaling and how these processes affect dopaminergic behavior and neurotransmission in the brain reward system. Subsequently, I completed my postdoctoral fellowship in the laboratory of Dr. Marc Caron at Duke University, where I focused on the molecular pharmacology of GPCR 'biased signaling' (a.k.a. functional selectivity) and its role in mediating the effects neuroendocrine hormones on brain dopamine and metabolic homeostasis. In August 2023, I began a faculty position at Penn State University (University Park) as a tenure-track Assistant Professor in the Depts. of Nutritional Sciences (co-hire with the Huck Institute of the Life Sciences) and Biobehavioral Health, as well as a secondary appointment in the Dept. of Pharmacology within the College of Medicine (Hershey, PA). As Director of the Nutritional Neuropharmacology Laboratory at PSU, I will investigate the molecular mechanisms underlying food reward and its downstream dysregulation of metabolism, particularly in response to obesogenic 'Western' diets. My laboratory will employ an array of basic science techniques — ranging from molecular pharmacology to behavioral/physiological analyses using genetically-engineered mice — to study how GPCR-dependent gut hormones (ghrelin, GLP-1), neurotransmitters (DA, serotonin), and dietary nutrients (fatty acids) regulate food reward in the context of obesity, eating disorders, and diabetes. By exploiting the precise signaling patterns of these 'druggable' GPCRs, I hope to rationally design/develop new medications or dietary interventions that maximize treatment efficacy and minimize side effects.
Joshua Gross’s Current Industry Duke University
Joshua
Gross’s Prior Industry
West Virginia University
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Duke University
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Work Experience

Duke University
Postdoctoral Researcher
Thu Aug 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Jul 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
West Virginia University
Ph.D. Graduate Student
Fri Aug 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Jul 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time)