
Matthew Naylor
I am a medicinal chemist interested in prosecuting hits from chemical discovery platforms that bring bRo5 chemical therapeutics... | Greater Boston, Greater Boston, United States
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Matthew Naylor’s Emails ma****@uc****.com
Matthew Naylor’s Phone Numbers No phone number available.
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Matthew Naylor’s Location Greater Boston, Greater Boston, United States
Matthew Naylor’s Expertise I am a medicinal chemist interested in prosecuting hits from chemical discovery platforms that bring bRo5 chemical therapeutics (peptides, oligonucleotides, PROTAC/glues) to intracellular targets or specific tissues, or via oral delivery, to address debilitating human disease. Success in this large chemical space requires well-designed chemical screening (synthetic libraries, OBOC, mRNA-display, DNA-encoded libraries), integrated cheminformatics + data analytics (library analysis, sequence-activity analysis, machine learning), structural modeling + analysis, and creative synthetic followup to permute hits into chemical space far outside of the initial hit. Our industry's ability to harness the rapid development of ML algorithms requires a close integration between chemist and data scientist to produce data of large quantity and quality for training and testing these models. Although trained in synthetic organic chemistry and chemical biology, I have worked in the industrial design+synthesis of passively membrane-permeable peptide macrocycles (including analytical property measurement), various screening library design+synthesis strategies, lead ID medchem followup, and CRO synthesis management. In these capacities I have built or applied various computational tools, notably: Spotfire (data analysis), CCG MOE (molecular modeling, NMR), rdkit/pandas (custom data analysis projects), Thermo Tracefinder (analytical LCMS quant), HELM+peptide informatics.
Matthew Naylor’s Current Industry Vc Backed Biotech Newco
Matthew
Naylor’s Prior Industry
Amgen
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Berkeley Lab
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Princeton University
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Uc Santa Cruz
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Eli Lilly
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Unnatural Products
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Ra Pharmaceuticals
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Ucb Ra Pharma
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Vc Backed Biotech Newco
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Work Experience

Vc Backed Biotech Newco
Associate Principal Scientist
Sun Oct 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Ucb Ra Pharma
Senior Scientist
Wed Apr 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun Oct 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Ra Pharmaceuticals
Scientist
Tue Jan 01 2019 00:00:00 GMT+0000 (Coordinated Universal Time) — Wed Apr 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Unnatural Products
Contractor
Mon Oct 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Dec 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Uc Santa Cruz
Postdoctoral Fellow
Wed Oct 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Oct 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Eli Lilly
Postdoctoral Fellow
Wed Oct 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Oct 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Princeton University
Chemistry Graduate Student
Sat Sep 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Sep 01 2014 00:00:00 GMT+0000 (Coordinated Universal Time)
Berkeley Lab
Student Intern
Mon Jan 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Jun 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time)
Amgen
Intern
Wed Jun 01 2005 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Aug 01 2005 00:00:00 GMT+0000 (Coordinated Universal Time)