
Stephen Hale
Steve has over 25 years of drug discovery experience, most recently as: -CEO and Founder of DG Medicines -An operational... | Cambridge, Massachusetts, United States
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Stephen Hale’s Emails sh****@en****.com
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Stephen Hale’s Location Cambridge, Massachusetts, United States
Stephen Hale’s Expertise Steve has over 25 years of drug discovery experience, most recently as: -CEO and Founder of DG Medicines -An operational founder and Global Head of Discovery at Dewpoint Therapeutics -A founder of 2 autoimmune-focused therapeutics companies; A founding member of an E3 Ligase-targeting company in the oncology and neuro-degeneration therapeutic areas. -A consultant and entrepreneur advising over 30 emerging and established companies Prior to consulting and venture creation, Steve was CSO of Ensemble Therapeutics where he built a drug discovery platform supporting 6 major collaborations that raised over 100M in non-dilutive capital. At Ensemble he was responsible for initiating and advancing internal and partnered programs that leveraged DNA-encoded macrocyclic compound collections and a massively parallel screening process. Programs were advanced in oncology, immune modulation, cardiovascular, neurodegeneration, and anti-infectives with an IL17, and IDO antagonists of novel mechanism being acquired and advanced towards the clinic. Before joining Ensemble, Steve was at Praecis Pharmaceuticals where he was co-inventor of a transformative DNA-Encoded Library (DEL) and screening technology that has since become ubiquitous in the industry as the gold-standard for encoded-small-molecule discovery. Programs in oncology were advanced including the approval of Plenaxis for prostate cancer prior to an acquisition by GSK. He joined Praecis from Phylos (Adnexus/BMS), a therapeutics discovery and development company where he was a founding scientist and led the anti-VEGFR2 program (BMS844203) that progressed to phase 2. Dr. Hale was also involved in early work at Genex Inc. on the design and engineering of single-chain antibodies. He received his Ph.D. in biochemistry/chemistry from the University of Maryland, College Park, under Professor John Gerlt and was a National Institutes of Health post-doctoral fellow at the Massachusetts Institute of Technology under the direction of Professor Paul Schimmel.
Stephen Hale’s Current Industry Stablix
Stephen
Hale’s Prior Industry
Normandeau Associates
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Eks Center Harvard Medical School
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Genex
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Massachusetts Institute Of Technology
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Phylos
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Praecis
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Ensemble Therapeutics
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Biotech Pharma And Venture Capital
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Dewpoint Therapeutics
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Dg Medicines
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Totus Medicines
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Work Experience

Stablix
Scientific Advisory Board member
Mon Nov 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Totus Medicines
Scientific Advisory Board member
Fri Oct 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Dg Medicines
Founder and CEO
Thu Jul 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Dewpoint Therapeutics
SVP, Global Head of R & D
Mon Oct 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Sep 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Biotech Pharma And Venture Capital
Independent Consultant
Sun Jan 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
Ensemble Therapeutics
Chief Scientific Officer
Sun May 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon May 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Ensemble Therapeutics
SVP, Discovery and Preclinical Development
Fri Nov 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun May 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time)
Ensemble Therapeutics
Vice President, Discovery and Preclinical Development
Tue Dec 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Nov 01 2013 00:00:00 GMT+0000 (Coordinated Universal Time)
Ensemble Therapeutics
Sr. Director, Discovery
Sat Apr 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Dec 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time)
Praecis
Sr. Director, Lead Discovery
Sat Jan 01 2005 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun Jan 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time)
Praecis
Director, Lead Discovery
Thu Jan 01 2004 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Jan 01 2005 00:00:00 GMT+0000 (Coordinated Universal Time)
Praecis
Director, Molecular Technologies
Tue Jan 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time) — Thu Jan 01 2004 00:00:00 GMT+0000 (Coordinated Universal Time)
Phylos
Director, Discovery Technologies
Mon Jan 01 2001 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Jan 01 2002 00:00:00 GMT+0000 (Coordinated Universal Time)
Phylos
Group Leader / Lab Head
Fri Jan 01 1999 00:00:00 GMT+0000 (Coordinated Universal Time) — Mon Jan 01 2001 00:00:00 GMT+0000 (Coordinated Universal Time)
Phylos
Sr. Research Scientist
Thu Jan 01 1998 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Jan 01 1999 00:00:00 GMT+0000 (Coordinated Universal Time)
Phylos
Founding Scientist
Wed Jan 01 1997 00:00:00 GMT+0000 (Coordinated Universal Time) — Thu Jan 01 1998 00:00:00 GMT+0000 (Coordinated Universal Time)
Massachusetts Institute Of Technology
NIH/NRSA Postdoctoral Fellow
Sat Jan 01 1994 00:00:00 GMT+0000 (Coordinated Universal Time) — Wed Jan 01 1997 00:00:00 GMT+0000 (Coordinated Universal Time)
Genex
Research Associate
Fri Jan 01 1988 00:00:00 GMT+0000 (Coordinated Universal Time) — Sun Jan 01 1989 00:00:00 GMT+0000 (Coordinated Universal Time)
Eks Center Harvard Medical School
Research Associate
Wed Jan 01 1986 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Jan 01 1988 00:00:00 GMT+0000 (Coordinated Universal Time)
Normandeau Associates
Research Consultant
Tue Jan 01 1985 00:00:00 GMT+0000 (Coordinated Universal Time) — Wed Jan 01 1986 00:00:00 GMT+0000 (Coordinated Universal Time)