
Wenwei Lin
• Innovative and self-motivated chemical biologist with a solid trackable record in chemical probe identification and further exploration, via... | Memphis, Tennessee, United States
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Wenwei Lin’s Emails we****@st****.org
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Wenwei Lin’s Location Memphis, Tennessee, United States
Wenwei Lin’s Expertise • Innovative and self-motivated chemical biologist with a solid trackable record in chemical probe identification and further exploration, via a typical evidence or experiment-based approach (application of a typical chemistry approach to address biology questions) • Strong expertise in the field of biochemical, biophysical, and cell-based assay as well as assay reagent development, especially for those reagents and assays suitable for HTS; great capability in developing associated assay reagents (such as biotinylated or fluorescently labeled bioconjugates) for macromolecules (proteins, DNAs and RNAs) and further assembling them into assays or assay ready kits (de novo assay reagent development mostly suitable for HTS) • Extensive knowledge, hands-on experience in activity-based small molecular hit identification, hit-to-lead optimization as well as structure-activity relationship study in the field of early stage drug discovery (preclinical, with a typical medicinal chemistry approach along with ADME/DMPK consideration); ligand potency, efficacy, selectivity, kinetics and mechanism of action characterizations • Major working areas: nuclear receptors (representative long term projects: PXR and CAR in NRs), epigenetics, kinases, GPCR, cell membrane transporters, enzymes, oncology, drug resistance and metabolic diseases • Typical interactions of interest: protein-small molecule, protein-peptide, protein-protein and protein-DNA (RNA) • Typical assay readouts or detections: ABS, FI, FP, FRET, TR-FRET, AlphaScreen, luminescence and BLI • Low and high throughput screening/assay (typically with 384-well plates for HTS) • Work with automated Agilent BioCel and HighRes screening systems • Data Analysis and storage: Excel, GraphPad Prism, Pipeline Pilot data analysis and CDD Vault data storage • Actively convert data to summaries, presentations, reports, publications and patent applications
Wenwei Lin’s Current Industry St Jude Childrens Research Hospital
Wenwei
Lin’s Prior Industry
Chinese Academy Of Medical Sciences And Peking Union Medical College
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St Jude Childrens Research Hospital
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Work Experience

St Jude Childrens Research Hospital
Principal HTS Scientist
Fri Dec 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time) — Present
St Jude Childrens Research Hospital
HTS Specialist
Sat Dec 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time) — Fri Dec 01 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
St Jude Childrens Research Hospital
Senior HTS Technologist
Tue Dec 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Dec 01 2012 00:00:00 GMT+0000 (Coordinated Universal Time)
St Jude Childrens Research Hospital
Senior Research Technologist in HTS
Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) — Tue Dec 01 2009 00:00:00 GMT+0000 (Coordinated Universal Time)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Junior Researcher
Thu Aug 01 1996 00:00:00 GMT+0000 (Coordinated Universal Time) — Sat Aug 01 1998 00:00:00 GMT+0000 (Coordinated Universal Time)